DL
Top 1% — Elite
David Liu
Chemical Biology · Genome Editing
Cambridge, United States
120 H-Index
1,589 Total Impact
GLBreakthrough Prize in Life Sciences (2023)0
Overview
David Liu is a chemical biology specialist with an H-index of 120 at Harvard and the Broad Institute. Invented base editing and prime editing for precision genome correction. Based in Cambridge, United States.
For Patients
- Pioneered 2 medical techniques including Base editing (cytosine and adenine base editors) and Prime editing
- Currently at Harvard University in Cambridge, United States
Biography
David Liu is an American chemical biologist who invented base editing and prime editing, revolutionary CRISPR-derived genome editing technologies that can precisely correct DNA mutations without double-strand breaks. His tools can address the majority of known pathogenic point mutations in humans.
Affiliations & Institutions
Research Impact
3 Publications
0 Total Citations
Published In
Nature
Key Publications
Programmable base editing of A*T to G*C in genomic DNA without DNA cleavage
Search-and-replace genome editing without double-strand breaks or donor DNA
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Areas of Expertise
Pioneering Techniques
Medical Specialties
Clinical Knowledge & Procedures
Legacy Timeline
The life and contributions of David Liu
2016
Invented cytosine base editing
Created the first base editor that converts C-G base pairs to T-A without double-strand breaks
2017
Invented adenine base editing
Developed adenine base editors that convert A-T to G-C pairs, covering the majority of disease mutations
2019
Invented prime editing
Created 'search-and-replace' genome editing that can make all 12 types of point mutations plus insertions and deletions
2023
Breakthrough Prize in Life Sciences
Awarded for the invention of base editing and prime editing