Gregg Semenza

Specialty: Genetics (Genetics)

Location: Baltimore, United States

Tier: TITAN

H-Index: 185

Years Active: 0

Hospital Affiliations

• Johns Hopkins University - C. Michael Armstrong Professor of Medicine

Techniques Invented

• HIF-1 discovery [Gold Standard]

Key Publications

1. "Targeting HIF-1 for cancer therapy" - Nature reviews. Cancer (2003) [6656 citations]
2. "Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension." - Proceedings of the National Academy of Sciences (1995) [6181 citations]
3. "Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1" - Molecular and Cellular Biology (1996) [3953 citations]
4. "HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia" - Cell Metabolism (2006) [3840 citations]
5. "Hypoxia-Inducible Factors in Physiology and Medicine" - Cell (2012) [3340 citations]
6. "Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α" - Genes & Development (1998) [2471 citations]
7. "A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation." - Molecular and Cellular Biology (1992) [2445 citations]
8. "Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases." - PubMed (1999) [2216 citations]
9. "Purification and Characterization of Hypoxia-inducible Factor 1" - Journal of Biological Chemistry (1995) [2067 citations]
10. "Regulation of Mammalian O₂Homeostasis by Hypoxia-Inducible Factor 1" - Annual Review of Cell and Developmental Biology (1999) [1937 citations]

Knowledge Graph Relationships

Gregg Semenza is a Genetics specialist affiliated with Johns Hopkins University. Invented techniques: HIF-1 discovery. Authored 10 scholarly articles.