LJ
Overview
Lenore J. Launer is a neuroepidemiology specialist with an H-index of 181 at National Institutes of Health (Faculty). Has been published in Nature, The Lancet Neurology, Nature Genetics. Based in United States.
Biography
The common disease-common variant hypothesis predicts that common disease-causing alleles, or variants, will be found in all human populations which manifest a given disease. Common variants are known to exist in coding and regulatory sequences of genes. According to the CD-CV hypothesis, some of those variants lead to susceptibility to complex polygenic diseases. Each variant at each gene influencing a complex disease will have a small additive or multiplicative effect on the disease phenotype. These diseases, or traits, are evolutionarily neutral in part because so many genes influence the traits. The hypothesis has held in the case of putative causal variants in apolipoprotein E, including APOE ε4, associated with Alzheimer's disease. IL23R has been found to be associated with Crohn's disease; the at-risk allele has a frequency of 93% in the general population.
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Research Impact
5 Publications
0 Total Citations
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Published In
Nat GenetNature