Oliver Smithies

Specialty: Genetics (Genetics)

Location: Chapel Hill, United Kingdom

Tier: TITAN

H-Index: 108

Years Active: 0

Hospital Affiliations

• University of North Carolina at Chapel Hill - Former Excellence Professor

Techniques Invented

• Gel electrophoresis (1955) [Gold Standard]
• Gene targeting in embryonic stem cells [Gold Standard]

Key Publications

1. "A comprehensive set of sequence analysis programs for the VAX" - Nucleic Acids Research (1984) [14422 citations]
2. "Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults" - Biochemical Journal (1955) [2808 citations]
3. "Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene." - Proceedings of the National Academy of Sciences (1993) [1845 citations]
4. "Generation and reproductive phenotypes of mice lacking estrogen receptor β" - Proceedings of the National Academy of Sciences (1998) [1695 citations]
5. "An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals" - Biochemical Journal (1959) [1344 citations]
6. "Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration" - Cell (1995) [1124 citations]
7. "Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse" - Cell (1995) [1086 citations]
8. "Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination" - Nature (1985) [993 citations]
9. "Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning" - Science (1977) [930 citations]
10. "An Animal Model for Cystic Fibrosis Made by Gene Targeting" - Science (1992) [919 citations]

Knowledge Graph Relationships

Oliver Smithies is a Genetics specialist affiliated with University of North Carolina at Chapel Hill. Invented techniques: Gel electrophoresis, Gene targeting in embryonic stem cells. Authored 10 scholarly articles.