Susumu Tonegawa
Immunology · Molecular Immunology
Cambridge, Japan
Overview
Susumu Tonegawa is an immunology and neuroscience specialist with an H-index of 130 at MIT. Nobel Prize 1987 for discovering the genetic mechanism of antibody diversity. Based in Cambridge, United States.
For Patients
- Research is cited 18K+ times by other doctors and scientists, indicating significant influence on medical research
- Currently at Massachusetts Institute of Technology in Cambridge, Japan
Biography
Affiliations & Institutions
Research Impact
Publication Timeline
Published In
Key Publications
Somatic generation of antibody diversity
RAG-1-deficient mice have no mature B and T lymphocytes
The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory
Optogenetic stimulation of a hippocampal engram activates fear memory recall
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Areas of Expertise
Medical Specialties
Clinical Knowledge & Procedures
Legacy Timeline
The life and contributions of Susumu Tonegawa
Discovered V(D)J recombination
Demonstrated how antibody genes rearrange to produce diverse antibodies from limited genetic material
Nobel Prize in Physiology or Medicine
Sole recipient for discovery of genetic principle for generation of antibody diversity
Pivoted to neuroscience
Established neuroscience laboratory at MIT to study memory and learning
Identified memory engram cells
Used optogenetics to activate specific memory traces in the hippocampus