William Kaelin

Specialty: Oncology (Oncology)

Location: Boston, United States

Tier: TITAN

H-Index: 138

Years Active: 0

Hospital Affiliations

• Dana-Farber Cancer Institute - Professor of Medicine
• Harvard Medical School - Sidney Farber Professor of Medicine

Key Publications

1. "HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing" - Science (2001) [4669 citations]
2. "Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway" - Molecular Cell (2008) [3199 citations]
3. "Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein" - Nature Cell Biology (2000) [1582 citations]
4. "The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins" - Science (2013) [1535 citations]
5. "The Concept of Synthetic Lethality in the Context of Anticancer Therapy" - Nature reviews. Cancer (2005) [1389 citations]
6. "Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex" - Genes & Development (2004) [1370 citations]
7. "Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma" - Science (2018) [1281 citations]
8. "p73 is a human p53-related protein that can induce apoptosis" - Nature (1997) [952 citations]
9. "Role of<i>VHL</i>Gene Mutation in Human Cancer" - Journal of Clinical Oncology (2004) [935 citations]
10. "The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage" - Nature (1999) [928 citations]

Knowledge Graph Relationships

William Kaelin is a Oncology specialist affiliated with Dana-Farber Cancer Institute, Harvard Medical School. Authored 10 scholarly articles.