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David M. Holtzman
United States
203 H-Index
2,892 Total Impact
Overview
David M. Holtzman is a neurodegenerative disease specialist with an H-index of 203 at Washington University (Faculty). Has been published in New England Journal of Medicine, Cell, Nature Reviews Disease Primers. Based in United States.
Biography
David M. Holtzman is an American physician-scientist known for his work exploring the biological mechanisms underlying neurodegeneration, with a focus on Alzheimer's disease. Holtzman is former Chair of the Department of Neurology, Scientific Director of the Hope Center for Neurological Disorders, and associate director of the Knight Alzheimer's Disease Research Center at Washington University School of Medicine in St. Louis, Missouri. Holtzman's lab is known for examining how apoE4 contributes to Alzheimer's disease as well as how sleep modulates amyloid beta in the brain. His work has also examined the contributions of microglia to AD pathology.
Affiliations & Institutions
Research Impact
5 Publications
0 Total Citations
Publication Timeline
Published In
Nat Rev Dis PrimersCellImmunityNature
Key Publications
Alzheimer disease.
Hallmarks of neurodegenerative diseases.
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies.
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy.
Areas of Expertise
Medical Specialties
Media Archive