MD
Top 1% — Elite
Mitch Dowsett
Breast Cancer Endocrine Therapy
United Kingdom
146 H-Index
1,764 Total Impact
Overview
Mitch Dowsett is a breast cancer endocrine therapy specialist with an H-index of 146 at Royal Marsden Hospital (Faculty). Has been published in New England Journal of Medicine, The Lancet, Science. Based in United Kingdom.
Biography
Steroidal aromatase inhibitors are a class of drugs that are mostly used for treating breast cancer in postmenopausal women. High levels of estrogen in breast tissue increases the risk of developing breast cancer and the enzyme aromatase is considered to be a good therapeutic target when treating breast cancer due to it being involved in the final step of estrogen biosynthetic pathway and also its inhibition will not affect production of other steroids. Aromatase Inhibitors are classified into two categories based on their structure, nonsteroidal and steroidal; the latter resemble the structure of androstenedione. Steroidal aromatase inhibitors irreversibly inhibit the enzyme by binding covalently to the binding site of aromatase so the substrate cannot access it.
Affiliations & Institutions
Research Impact
5 Publications
0 Total Citations
Publication Timeline
Published In
N Engl J MedJ Natl Cancer InstLancetCancer Res