Ruth Nussenzweig — MDRPedia
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Ruth Nussenzweig

Parasitology · Malaria Immunology

New York, Brazil

70 H-Index
5,500 Citations
790 Total Impact

Overview

Ruth Nussenzweig was a parasitology and immunology specialist with an H-index of 70 at NYU School of Medicine. Pioneer of malaria vaccine research whose work led to the RTS,S vaccine. Based in New York, United States.

For Patients

  • Pioneered the Irradiated sporozoite malaria vaccination approach, a technique still used by doctors worldwide
  • Research was cited 6K+ times by other doctors and scientists
  • Based at New York University School of Medicine in New York, Brazil

Biography

Ruth Nussenzweig was a Brazilian-American parasitologist who pioneered malaria vaccine research. She was the first to demonstrate that irradiated sporozoites could protect against malaria infection in 1967, and her identification of the circumsporozoite protein laid the foundation for the RTS,S malaria vaccine (Mosquirix).

Affiliations & Institutions

Research Impact

10 Publications
5,500 Total Citations
5K+ Citation Milestone

Publication Timeline

0121967198019851987198919972001

Published In

NatureCellScienceThe Journal of Experimental Medicine

Areas of Expertise

Pioneering Techniques

Irradiated sporozoite malaria vaccination approach

Medical Specialties

Legacy Timeline

The life and contributions of Ruth Nussenzweig

1967

Demonstrated irradiated sporozoites protect against malaria

Published landmark paper showing immunization with irradiated sporozoites prevents malaria infection

1970

Identified circumsporozoite protein

Discovered the major surface protein of Plasmodium sporozoites

1984

Cloned circumsporozoite protein gene

Enabled molecular development of subunit malaria vaccines

2015

RTS,S vaccine approved by WHO

The Mosquirix malaria vaccine, built on her foundational work, received WHO recommendation