William Kaelin Jr.

Specialty: Nobel Prize in Physiology or Medicine

Location: Unknown, Unknown, Global

Tier: UNRANKED

H-Index: 137

Years Active: 0

Key Publications

1. "HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing" - Science (2000)
2. "Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway" - Molecular Cell (2007)
3. "Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein" - Nature Cell Biology (1999)
4. "The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins" - Science (2012)
5. "The Concept of Synthetic Lethality in the Context of Anticancer Therapy" - Nature reviews. Cancer (2004)
6. "Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex" - Genes & Development (2003)
7. "Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma" - Science (2017)
8. "p73 is a human p53-related protein that can induce apoptosis" - Nature (1996)
9. "Role of<i>VHL</i>Gene Mutation in Human Cancer" - Journal of Clinical Oncology (2003)
10. "The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage" - Nature (1998)

Knowledge Graph Relationships

William Kaelin Jr. is a Nobel Prize in Physiology or Medicine specialist . Authored 10 scholarly articles.